Reaction Details
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Corticotropin-releasing factor-binding protein
Ligand
BDBM90892
Substrate
n/a
IC50
3100±n/a nM
Citation
PubChem, PC Dose Response confirmation of uHTS hits for small molecule antagonists of the CRF-binding protein and CRF-R2 receptor complex in 384 well format PubChem Bioassay (2012)[AID] More Info.:
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
Inhibitor
Name:
BDBM90892
Synonyms:
2-(4-chlorophenyl)sulfanyl-3-nitro-pyridine | 2-(4-chlorophenyl)sulfanyl-3-nitropyridine | 2-[(4-chlorophenyl)thio]-3-nitro-pyridine | 2-[(4-chlorophenyl)thio]-3-nitropyridine | MLS001181424 | SMR000567168 | cid_2774370
Type:
Small organic molecule
Emp. Form.:
C11H7ClN2O2S
Mol. Mass.:
266.703
SMILES:
[O-][N+](=O)c1cccnc1Sc1ccc(Cl)cc1
Structure:
