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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM90508
Substrate
n/a
IC50
3740±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule antagonists of the CRF-binding protein and CRF-R2 receptor complex in 384 well format PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM90508
Synonyms:
2-(3,5-dimethylanilino)-3,4,5,6-tetrafluoro-benzoic acid | 2-(3,5-dimethylanilino)-3,4,5,6-tetrafluorobenzoic acid | 2-[(3,5-dimethylphenyl)amino]-3,4,5,6-tetrafluorobenzoic acid | 2-[(3,5-dimethylphenyl)amino]-3,4,5,6-tetrakis(fluoranyl)benzoic acid | MLS000689735 | SMR000313339 | cid_4549148
Type:
Small organic molecule
Emp. Form.:
C15H11F4NO2
Mol. Mass.:
313.247
SMILES:
Cc1cc(C)cc(Nc2c(F)c(F)c(F)c(F)c2C(O)=O)c1
Structure:
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