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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM91148
Substrate
n/a
IC50
4530±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule antagonists of the CRF-binding protein and CRF-R2 receptor complex in 384 well format PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM91148
Synonyms:
2-(4-carbethoxyphenyl)imino-4-keto-3-(3-morpholinopropyl)-1,3-thiazine-6-carboxylic acid methyl ester;hydrochloride | 2-(4-ethoxycarbonylphenyl)imino-3-[3-(4-morpholinyl)propyl]-4-oxo-1,3-thiazine-6-carboxylic acid methyl ester;hydrochloride | MLS001367603 | SMR000102073 | cid_6603300 | methyl (2Z)-2-{[4-(ethoxycarbonyl)phenyl]imino}-3-(3-morpholin-4-ylpropyl)-4-oxo-3,4-dihydro-2H-1,3-thiazine-6-carboxylate | methyl 2-(4-ethoxycarbonylphenyl)imino-3-(3-morpholin-4-ylpropyl)-4-oxidanylidene-1,3-thiazine-6-carboxylate;hydrochloride | methyl 2-(4-ethoxycarbonylphenyl)imino-3-(3-morpholin-4-ylpropyl)-4-oxo-1,3-thiazine-6-carboxylate;hydrochloride
Type:
Small organic molecule
Emp. Form.:
C22H27N3O6S
Mol. Mass.:
461.531
SMILES:
CCOC(=O)c1ccc(cc1)\N=c1/sc(cc(=O)n1CCCN1CCOCC1)C(=O)OC
Structure:
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