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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM89544
Substrate
n/a
IC50
3720±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule antagonists of the CRF-binding protein and CRF-R2 receptor complex in 384 well format PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM89544
Synonyms:
(2,4-Dimethoxy-phenyl)-[6-(2-fluoro-phenyl)-pyridazin-3-yl]-amine | (2,4-dimethoxyphenyl)-[6-(2-fluorophenyl)pyridazin-3-yl]amine | MLS000075679 | N-(2,4-dimethoxyphenyl)-6-(2-fluorophenyl)-3-pyridazinamine | N-(2,4-dimethoxyphenyl)-6-(2-fluorophenyl)pyridazin-3-amine | SMR000007238 | cid_653238
Type:
Small organic molecule
Emp. Form.:
C18H16FN3O2
Mol. Mass.:
325.3369
SMILES:
COc1ccc(Nc2ccc(nn2)-c2ccccc2F)c(OC)c1
Structure:
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