Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM90162
Substrate
n/a
IC50
1670±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule antagonists of the CRF-binding protein and CRF-R2 receptor complex in 384 well format PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM90162
Synonyms:
(2-fluorophenyl)methyl N-cyano-N'-(3-fluorophenyl)carbamimidothioate | 1-cyano-2-(2-fluorobenzyl)-3-(3-fluorophenyl)isothiourea | MLS000592109 | N-cyano-N'-(3-fluorophenyl)carbamimidothioic acid (2-fluorophenyl)methyl ester | SMR000218316 | cid_1947246
Type:
Small organic molecule
Emp. Form.:
C15H11F2N3S
Mol. Mass.:
303.33
SMILES:
Fc1cccc(c1)N=C(NC#N)SCc1ccccc1F |w:7.7|
Structure:
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