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Target
Neuropilin-1
Ligand
BDBM94079
Substrate
n/a
IC50
>95000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of small molecule modulators of the interaction between CendR and NRP-1 in a panel assay PubChem Bioassay (2012)[AID] 
Target
Name:
Neuropilin-1
Synonyms:
Chain A, Crystal Structure Of The B1b2 Domains From Human Neuropilin- 1 | NRP | NRP1 | NRP1_HUMAN | Neuropilin-1 | VEGF165R
Type:
PROTEIN
Mol. Mass.:
103122.09
Organism:
Homo sapiens (Human)
Description:
ChEMBL_617636
Residue:
923
Sequence:
MERGLPLLCAVLALVLAPAGAFRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFVPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYSTNWSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSYINEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTFPALSTRFIRIYPERATHGGLGLRMELLGCEVEAPTAGPTTPNGNLVDECDDDQANCHSGTGDDFQLTGGTTVLATEKPTVIDSTIQSEFPTYGFNCEFGWGSHKTFCHWEHDNHVQLKWSVLTSKTGPIQDHTGDGNFIYSQADENQKGKVARLVSPVVYSQNSAHCMTFWYHMSGSHVGTLRVKLRYQKPEEYDQLVWMAIGHQGDHWKEGRVLLHKSLKLYQVIFEGEIGKGNLGGIAVDDISINNHISQEDCAKPADLDKKNPEIKIDETGSTPGYEGEGEGDKNISRKPGNVLKTLDPILITIIAMSALGVLLGAVCGVVLYCACWHNGMSERNLSALENYNFELVDGVKLKKDKLNTQSTYSEA
  
Inhibitor
Name:
BDBM94079
Synonyms:
2-ethyl-4-[4-(2-furoyl)piperazine-1-carbonyl]-6,7-dimethoxy-isocarbostyril | 2-ethyl-4-[4-(furan-2-carbonyl)piperazine-1-carbonyl]-6,7-dimethoxyisoquinolin-1-one | 2-ethyl-4-[4-(furan-2-ylcarbonyl)piperazin-1-yl]carbonyl-6,7-dimethoxy-isoquinolin-1-one | 2-ethyl-4-[[4-[2-furanyl(oxo)methyl]-1-piperazinyl]-oxomethyl]-6,7-dimethoxy-1-isoquinolinone | 2-ethyl-4-{[4-(2-furoyl)piperazin-1-yl]carbonyl}-6,7-dimethoxyisoquinolin-1(2H)-one | MLS000086160 | SMR000021669 | cid_3240885
Type:
Small organic molecule
Emp. Form.:
C23H25N3O6
Mol. Mass.:
439.4611
SMILES:
CCn1cc(C(=O)N2CCN(CC2)C(=O)c2ccco2)c2cc(OC)c(OC)cc2c1=O
Structure:
Search PDB for entries with ligand similarity: