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Target
Neuropilin-1
Ligand
BDBM94088
Substrate
n/a
IC50
>95000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of small molecule modulators of the interaction between CendR and NRP-1 in a panel assay PubChem Bioassay (2012)[AID] 
Target
Name:
Neuropilin-1
Synonyms:
Chain A, Crystal Structure Of The B1b2 Domains From Human Neuropilin- 1 | NRP | NRP1 | NRP1_HUMAN | Neuropilin-1 | VEGF165R
Type:
PROTEIN
Mol. Mass.:
103122.09
Organism:
Homo sapiens (Human)
Description:
ChEMBL_617636
Residue:
923
Sequence:
MERGLPLLCAVLALVLAPAGAFRNDKCGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDYVEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFVPKMSEIILEFESFDLEPDSNPPGGMFCRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVLQSSVSEDFKCMEALGMESGEIHSDQITASSQYSTNWSAERSRLNYPENGWTPGEDSYREWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVLFQGNTNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITDYPCSGMLGMVSGLISDSQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSYINEWLQIDLGEEKIVRGIIIQGGKHRENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTFPALSTRFIRIYPERATHGGLGLRMELLGCEVEAPTAGPTTPNGNLVDECDDDQANCHSGTGDDFQLTGGTTVLATEKPTVIDSTIQSEFPTYGFNCEFGWGSHKTFCHWEHDNHVQLKWSVLTSKTGPIQDHTGDGNFIYSQADENQKGKVARLVSPVVYSQNSAHCMTFWYHMSGSHVGTLRVKLRYQKPEEYDQLVWMAIGHQGDHWKEGRVLLHKSLKLYQVIFEGEIGKGNLGGIAVDDISINNHISQEDCAKPADLDKKNPEIKIDETGSTPGYEGEGEGDKNISRKPGNVLKTLDPILITIIAMSALGVLLGAVCGVVLYCACWHNGMSERNLSALENYNFELVDGVKLKKDKLNTQSTYSEA
  
Inhibitor
Name:
BDBM94088
Synonyms:
4-Hydroxy-2-(3-nitro-phenyl)-5-oxo-1-phenyl-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester | 4-hydroxy-2-(3-nitrophenyl)-5-oxo-1-phenyl-2H-pyrrole-3-carboxylic acid ethyl ester | 4-hydroxy-5-keto-2-(3-nitrophenyl)-1-phenyl-3-pyrroline-3-carboxylic acid ethyl ester | MLS000767615 | SMR000429945 | cid_54695555 | ethyl 2-(3-nitrophenyl)-4-oxidanyl-5-oxidanylidene-1-phenyl-2H-pyrrole-3-carboxylate | ethyl 4-hydroxy-2-(3-nitrophenyl)-5-oxo-1-phenyl-2H-pyrrole-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C19H16N2O6
Mol. Mass.:
368.3401
SMILES:
CCOC(=O)C1C(N(C(=O)C1=O)c1ccccc1)c1cccc(c1)[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: