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Target
Sentrin-specific protease 1
Ligand
BDBM46568
Substrate
n/a
IC50
428±n/a nM
Citation
 PubChem, PC Dose response confirmation of small molecule inhibitors of the catalytic domain of the SUMO protease, SENP1 in a FRET assay PubChem Bioassay (2012)[AID] 
Target
Name:
Sentrin-specific protease 1
Synonyms:
SENP1 | SENP1_HUMAN | Sentrin-specific protease 1 (SENP1)
Type:
Protein
Mol. Mass.:
73500.42
Organism:
Homo sapiens (Human)
Description:
Q9P0U3
Residue:
644
Sequence:
MDDIADRMRMDAGEVTLVNHNSVFKTHLLPQTGFPEDQLSLSDQQILSSRQGHLDRSFTCSTRSAAYNPSYYSDNPSSDSFLGSGDLRTFGQSANGQWRNSTPSSSSSLQKSRNSRSLYLETRKTSSGLSNSFAGKSNHHCHVSAYEKSFPIKPVPSPSWSGSCRRSLLSPKKTQRRHVSTAEETVQEEEREIYRQLLQMVTGKQFTIAKPTTHFPLHLSRCLSSSKNTLKDSLFKNGNSCASQIIGSDTSSSGSASILTNQEQLSHSVYSLSSYTPDVAFGSKDSGTLHHPHHHHSVPHQPDNLAASNTQSEGSDSVILLKVKDSQTPTPSSTFFQAELWIKELTSVYDSRARERLRQIEEQKALALQLQNQRLQEREHSVHDSVELHLRVPLEKEIPVTVVQETQKKGHKLTDSEDEFPEITEEMEKEIKNVFRNGNQDEVLSEAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLMERSKEKGLPSVHAFNTFFFTKLKTAGYQAVKRWTKKVDVFSVDILLVPIHLGVHWCLAVVDFRKKNITYYDSMGGINNEACRILLQYLKQESIDKKRKEFDTNGWQLFSKKSQEIPQQMNGSDCGMFACKYADCITKDRPINFTQQHMPYFRKRMVWEILHRKLL
  
Inhibitor
Name:
BDBM46568
Synonyms:
(2Z)-7-chloranyl-2-[(2E)-1-chloranyl-2-(3-chloranyl-6-oxidanylidene-cyclohexa-2,4-dien-1-ylidene)ethylidene]-1H-quinazolin-4-one | (2Z)-7-chloro-2-[(2E)-1-chloro-2-(3-chloro-6-keto-cyclohexa-2,4-dien-1-ylidene)ethylidene]-1H-quinazolin-4-one | (2Z)-7-chloro-2-[(2E)-1-chloro-2-(3-chloro-6-oxo-1-cyclohexa-2,4-dienylidene)ethylidene]-1H-quinazolin-4-one | (2Z)-7-chloro-2-[(2E)-1-chloro-2-(3-chloro-6-oxocyclohexa-2,4-dien-1-ylidene)ethylidene]-1H-quinazolin-4-one | MLS000394715 | SMR000242822 | cid_15945307
Type:
Small organic molecule
Emp. Form.:
C16H9Cl3N2O2
Mol. Mass.:
367.614
SMILES:
Oc1ccc(Cl)cc1C=C(Cl)c1nc2cc(Cl)ccc2c(=O)[nH]1 |w:9.10|
Structure:
Search PDB for entries with ligand similarity: