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Target
Sentrin-specific protease 1
Ligand
BDBM94846
Substrate
n/a
IC50
1150±n/a nM
Citation
 PubChem, PC Dose response confirmation of small molecule inhibitors of the catalytic domain of the SUMO protease, SENP1 in a FRET assay PubChem Bioassay (2012)[AID] 
Target
Name:
Sentrin-specific protease 1
Synonyms:
SENP1 | SENP1_HUMAN | Sentrin-specific protease 1 (SENP1)
Type:
Protein
Mol. Mass.:
73500.42
Organism:
Homo sapiens (Human)
Description:
Q9P0U3
Residue:
644
Sequence:
MDDIADRMRMDAGEVTLVNHNSVFKTHLLPQTGFPEDQLSLSDQQILSSRQGHLDRSFTCSTRSAAYNPSYYSDNPSSDSFLGSGDLRTFGQSANGQWRNSTPSSSSSLQKSRNSRSLYLETRKTSSGLSNSFAGKSNHHCHVSAYEKSFPIKPVPSPSWSGSCRRSLLSPKKTQRRHVSTAEETVQEEEREIYRQLLQMVTGKQFTIAKPTTHFPLHLSRCLSSSKNTLKDSLFKNGNSCASQIIGSDTSSSGSASILTNQEQLSHSVYSLSSYTPDVAFGSKDSGTLHHPHHHHSVPHQPDNLAASNTQSEGSDSVILLKVKDSQTPTPSSTFFQAELWIKELTSVYDSRARERLRQIEEQKALALQLQNQRLQEREHSVHDSVELHLRVPLEKEIPVTVVQETQKKGHKLTDSEDEFPEITEEMEKEIKNVFRNGNQDEVLSEAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLMERSKEKGLPSVHAFNTFFFTKLKTAGYQAVKRWTKKVDVFSVDILLVPIHLGVHWCLAVVDFRKKNITYYDSMGGINNEACRILLQYLKQESIDKKRKEFDTNGWQLFSKKSQEIPQQMNGSDCGMFACKYADCITKDRPINFTQQHMPYFRKRMVWEILHRKLL
  
Inhibitor
Name:
BDBM94846
Synonyms:
(5R)-3-(3-chloranyl-2-oxidanyl-phenyl)-5-(4-chlorophenyl)cyclohex-2-en-1-one | (5R)-3-(3-chloro-2-hydroxy-phenyl)-5-(4-chlorophenyl)cyclohex-2-en-1-one | (5R)-3-(3-chloro-2-hydroxyphenyl)-5-(4-chlorophenyl)-1-cyclohex-2-enone | (5R)-3-(3-chloro-2-hydroxyphenyl)-5-(4-chlorophenyl)cyclohex-2-en-1-one | MLS002302567 | SMR001318595 | cid_44143783
Type:
Small organic molecule
Emp. Form.:
C18H14Cl2O2
Mol. Mass.:
333.209
SMILES:
Oc1c(Cl)cccc1C1=CC(=O)C[C@@H](C1)c1ccc(Cl)cc1 |t:9|
Structure:
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