Reaction Details Report a problem with these data
Target
Hepatocyte nuclear factor 4-alpha
Ligand
BDBM94621
Substrate
n/a
IC50
>39845±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput dose response assay to identify inhibitors of Hepatocyte nuclear factor 4 (HNF4) dimerization PubChem Bioassay (2012)[AID] 
Target
Name:
Hepatocyte nuclear factor 4-alpha
Synonyms:
HNF4 | HNF4A | HNF4A_HUMAN | NR2A1 | TCF14 | hepatocyte nuclear factor 4-alpha isoform b
Type:
PROTEIN
Mol. Mass.:
52790.24
Organism:
Homo sapiens (Human)
Description:
ChEMBL_606516
Residue:
474
Sequence:
MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEWPRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI
  
Inhibitor
Name:
BDBM94621
Synonyms:
(E)-2-butenedioic acid;N-[2-(diethylamino)ethyl]-N-[2-oxo-2-(2,4,6-trimethylanilino)ethyl]benzamide | (E)-but-2-enedioic acid;N-[2-(diethylamino)ethyl]-N-[2-oxidanylidene-2-[(2,4,6-trimethylphenyl)amino]ethyl]benzamide | (E)-but-2-enedioic acid;N-[2-(diethylamino)ethyl]-N-[2-oxo-2-(2,4,6-trimethylanilino)ethyl]benzamide | MLS001212879 | N-(2-Diethylamino-ethyl)-N-[(2,4,6-trimethyl-phenylcarbamoyl)-methyl]-benzamide | N-[2-(diethylamino)ethyl]-N-(2-keto-2-mesidino-ethyl)benzamide;fumaric acid | SMR000516363 | cid_18527021
Type:
Small organic molecule
Emp. Form.:
C24H33N3O2
Mol. Mass.:
395.5377
SMILES:
CCN(CC)CCN(CC(=O)Nc1c(C)cc(C)cc1C)C(=O)c1ccccc1
Structure:
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