Reaction Details Report a problem with these data
Target
Hepatocyte nuclear factor 4-alpha
Ligand
BDBM94595
Substrate
n/a
IC50
1868±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput dose response assay to identify inhibitors of Hepatocyte nuclear factor 4 (HNF4) dimerization PubChem Bioassay (2012)[AID] 
Target
Name:
Hepatocyte nuclear factor 4-alpha
Synonyms:
HNF4 | HNF4A | HNF4A_HUMAN | NR2A1 | TCF14 | hepatocyte nuclear factor 4-alpha isoform b
Type:
PROTEIN
Mol. Mass.:
52790.24
Organism:
Homo sapiens (Human)
Description:
ChEMBL_606516
Residue:
474
Sequence:
MRLSKTLVDMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGTNLNAPNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSRQITSPVSGINGDIRAKKIASIADVCESMKEQLLVLVEWAKYIPAFCELPLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYAYLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSPSDAPHAHHPLHPHLMQEHMGTNVIVANTMPTHLSNGQMCEWPRPRGQAATPETPQPSPPGGSGSEPYKLLPGAVATIVKPLSAIPQPTITKQEVI
  
Inhibitor
Name:
BDBM94595
Synonyms:
(5Z)-1-(4-fluorobenzyl)-5-[(E)-3-(2-furyl)prop-2-enylidene]barbituric acid | (5Z)-1-[(4-fluorophenyl)methyl]-5-[(E)-3-(2-furanyl)prop-2-enylidene]-1,3-diazinane-2,4,6-trione | (5Z)-1-[(4-fluorophenyl)methyl]-5-[(E)-3-(furan-2-yl)prop-2-enylidene]-1,3-diazinane-2,4,6-trione | 1-(4-Fluoro-benzyl)-5-[(E)-3-furan-2-yl-prop-2-en-(E)-ylidene]-pyrimidine-2,4,6-trione | MLS000779343 | SMR000416057 | cid_873296
Type:
Small organic molecule
Emp. Form.:
C18H13FN2O4
Mol. Mass.:
340.3052
SMILES:
Fc1ccc(CN2C(=O)NC(=O)\C(=C\C=C\c3ccco3)C2=O)cc1
Structure:
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