Reaction Details
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ADP-ribosylation factor GTPase-activating protein 1
Ligand
BDBM54212
Substrate
n/a
IC50
30286±n/a nM
Citation
PubChem, PC Fluorescence polarization-based biochemical high throughput dose response screening assay to identify inhibitors of ADP-ribosylation factor GTPase activating protein 1 (ARFGAP1) PubChem Bioassay (2012)[AID] More Info.:
Target
Name:
ADP-ribosylation factor GTPase-activating protein 1
Synonyms:
ARFG1_RAT | Arf1gap | Arfgap1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45436.38
Organism:
Rattus norvegicus
Description:
gi_21489979
Residue:
415
Sequence:
MASPRTRKVLKEVRAQDENNVCFECGAFNPQWVSVTYGIWICLECSGRHRGLGVHLSFVRSVTMDKWKDIELEKMKAGGNAKFREFLEAQDDYEPSWSLQDKYSSRAAALFRDKVATLAEGKEWSLESSPAQNWTPPQPKTLQFTAHRPAGQPQNVTTSGDKAFEDWLNDDLGSYQGAQENRYVGFGNTVPPQKREDDFLNSAMSSLYSGWSSFTTGASKFASAAKEGATKFGSQASQKASELGHSLNENVLKPAQEKVKEGRIFDDVSSGVSQLASKVQGVGSKGWRDVTTFFSGKAEDTSDRPLEGHSYQNSSGDNSQNSTIDQSFWETFGSAEPPKAKSPSSDSWTCADASTGRRSSDSWDIWGSGSASNNKNSNSDGWESWEGASGEGRAKATKKAAPSTAADEGWDNQNW
Inhibitor
Name:
BDBM54212
Synonyms:
MLS000326804 | N'-[(2,6-dichlorobenzyl)oxy]-N-thieno[2,3-d]pyrimidin-4-yliminoformamide | N-(2,6-dichlorobenzyl)oxy-N'-thieno[2,3-d]pyrimidin-4-yl-formamidine | N-[(2,6-dichlorophenyl)methoxy]-N''-(4-thieno[2,3-d]pyrimidinyl)methanimidamide | N-[(2,6-dichlorophenyl)methoxy]-N''-thieno[2,3-d]pyrimidin-4-ylmethanimidamide | N-[[2,6-bis(chloranyl)phenyl]methoxy]-N''-thieno[2,3-d]pyrimidin-4-yl-methanimidamide | SMR000179376 | cid_2765831
Type:
Small organic molecule
Emp. Form.:
C14H10Cl2N4OS
Mol. Mass.:
353.226
SMILES:
Clc1cccc(Cl)c1CON=CNc1ncnc2sccc12 |w:10.10|
Structure:
