Reaction Details
Report a problem with these data
Report a problem with these dataTarget
ADP-ribosylation factor GTPase-activating protein 1
Ligand
BDBM95214
Substrate
n/a
IC50
38279±n/a nM
Citation
PubChem, PC Fluorescence polarization-based biochemical high throughput dose response screening assay to identify inhibitors of ADP-ribosylation factor GTPase activating protein 1 (ARFGAP1) PubChem Bioassay (2012)[AID] More Info.:
Target
Name:
ADP-ribosylation factor GTPase-activating protein 1
Synonyms:
ARFG1_RAT | Arf1gap | Arfgap1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45436.38
Organism:
Rattus norvegicus
Description:
gi_21489979
Residue:
415
Sequence:
MASPRTRKVLKEVRAQDENNVCFECGAFNPQWVSVTYGIWICLECSGRHRGLGVHLSFVRSVTMDKWKDIELEKMKAGGNAKFREFLEAQDDYEPSWSLQDKYSSRAAALFRDKVATLAEGKEWSLESSPAQNWTPPQPKTLQFTAHRPAGQPQNVTTSGDKAFEDWLNDDLGSYQGAQENRYVGFGNTVPPQKREDDFLNSAMSSLYSGWSSFTTGASKFASAAKEGATKFGSQASQKASELGHSLNENVLKPAQEKVKEGRIFDDVSSGVSQLASKVQGVGSKGWRDVTTFFSGKAEDTSDRPLEGHSYQNSSGDNSQNSTIDQSFWETFGSAEPPKAKSPSSDSWTCADASTGRRSSDSWDIWGSGSASNNKNSNSDGWESWEGASGEGRAKATKKAAPSTAADEGWDNQNW
Inhibitor
Name:
BDBM95214
Synonyms:
3-(2-Pyridin-3-yl-quinazolin-4-ylamino)-benzoic acid methyl ester | 3-[[2-(3-pyridinyl)-4-quinazolinyl]amino]benzoic acid methyl ester | 3-[[2-(3-pyridyl)quinazolin-4-yl]amino]benzoic acid methyl ester | MLS001029618 | SMR000426956 | cid_1186125 | methyl 3-[(2-pyridin-3-ylquinazolin-4-yl)amino]benzoate
Type:
Small organic molecule
Emp. Form.:
C21H16N4O2
Mol. Mass.:
356.3773
SMILES:
COC(=O)c1cccc(Nc2nc(nc3ccccc23)-c2cccnc2)c1
Structure:
