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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM405268
Substrate
n/a
Meas. Tech.
Activity Assay
IC50
0.110±n/a nM
Citation
 Lu, H; Sun, P; Gui, B; Dong, Q Pyrazolopyrimidone or Pyrrolotriazone derivatives, method of preparing same, and pharmaceutical applications thereof US Patent  US10344034 Publication Date 7/9/2019 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH)
Type:
Enzyme
Mol. Mass.:
37749.45
Organism:
Homo sapiens (Human)
Description:
P30968
Residue:
328
Sequence:
MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM405268
Synonyms:
1-(4-(7-(2,6-difluorobenzyl)-3-((dimethylamino)methyl)-5-(2-fluoro-3-methoxyphenyl)-4,6-dioxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-d]pyrimidin-2-yl)phenyl)-3-methylurea | US10344034, Example 14 | US10344034, Example 5 | US10633388, Example 5
Type:
Small organic molecule
Emp. Form.:
C30H28F3N7O4
Mol. Mass.:
607.583
SMILES:
CNC(=O)Nc1ccc(cc1)-n1nc2n(Cc3c(F)cccc3F)c(=O)n(-c3cccc(OC)c3F)c(=O)c2c1CN(C)C |(-9.14,-2.67,;-8.37,-1.33,;-6.83,-1.33,;-6.06,-2.67,;-6.06,,;-4.52,,;-3.75,-1.33,;-2.21,-1.33,;-1.44,,;-2.21,1.33,;-3.75,1.33,;.1,,;1.01,-1.25,;2.47,-.77,;3.8,-1.54,;3.8,-3.08,;5.14,-3.85,;6.47,-3.08,;7.81,-2.31,;7.81,-3.85,;7.81,-5.39,;6.47,-6.16,;5.14,-5.39,;3.8,-6.16,;5.14,-.77,;6.47,-1.54,;5.14,.77,;6.47,1.54,;7.81,.77,;9.14,1.54,;9.14,3.08,;7.81,3.85,;7.81,5.39,;6.47,6.16,;6.47,3.08,;5.14,3.85,;3.8,1.54,;3.8,3.08,;2.47,.77,;1.01,1.25,;.61,2.73,;-.88,3.13,;-1.28,4.62,;-1.97,2.04,)|
Structure:
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