Reaction Details Report a problem with these data
Target
Mitochondrial peptide methionine sulfoxide reductase
Ligand
BDBM95365
Substrate
n/a
IC50
99385±n/a nM
Citation
 PubChem, PC Absorbance-based biochemical high throughput dose response assay to identify inhibitors of Methionine sulfoxide reductase A (MsrA) PubChem Bioassay (2013)[AID] 
Target
Name:
Mitochondrial peptide methionine sulfoxide reductase
Synonyms:
MSRA | MSRA protein | MSRA_BOVIN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25822.90
Organism:
Bos taurus
Description:
gi_73586699
Residue:
233
Sequence:
MLSATRRALQLFHSLFPIPRMGDSAAKIVSPQEALPGRKEPLVVAAKHHVNGNRTVEPFPEGTQMAVFGMGCFWGAERKFWTLKGVYSTQVGFAGGYTPNPTYKEVCSGKTGHAEVVRVVFQPEHISFEELLKVFWENHDPTQGMRQGNDHGSQYRSAIYPTSAEHVGAALKSKEDYQKVLSEHGFGLITTDIREGQTFYYAEDYHQQYLSKDPDGYCGLGGTGVSCPLGIKK
  
Inhibitor
Name:
BDBM95365
Synonyms:
2-Chloro-5-(5-{[2-(3-cyano-4-methoxymethyl-6-methyl-2-oxo-2H-pyridin-1-yl)-acetyl]-hydrazonomethyl}-furan-2-yl)-benzoic acid | 2-chloranyl-5-[5-[(E)-[2-[3-cyano-4-(methoxymethyl)-6-methyl-2-oxidanylidene-pyridin-1-yl]ethanoylhydrazinylidene]methyl]furan-2-yl]benzoic acid | 2-chloro-5-[5-[(E)-[[2-[3-cyano-2-keto-4-(methoxymethyl)-6-methyl-1-pyridyl]acetyl]hydrazono]methyl]-2-furyl]benzoic acid | 2-chloro-5-[5-[(E)-[[2-[3-cyano-4-(methoxymethyl)-6-methyl-2-oxo-1-pyridinyl]-1-oxoethyl]hydrazinylidene]methyl]-2-furanyl]benzoic acid | 2-chloro-5-[5-[(E)-[[2-[3-cyano-4-(methoxymethyl)-6-methyl-2-oxopyridin-1-yl]acetyl]hydrazinylidene]methyl]furan-2-yl]benzoic acid | MLS000587768 | SMR000211828 | cid_6883942
Type:
Small organic molecule
Emp. Form.:
C23H19ClN4O6
Mol. Mass.:
482.873
SMILES:
COCc1cc(C)n(CC(=O)N\N=C\c2ccc(o2)-c2ccc(Cl)c(c2)C(O)=O)c(=O)c1C#N
Structure:
Search PDB for entries with ligand similarity: