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Target
Rho-associated protein kinase 2 [11-552]
Ligand
BDBM97666
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.2±0
Ki
10±0.0 nM
Citation
 Lampe, JW; Watson, PS; Slade, DJ Bridged bicyclic RHO kinase inhibitor compounds, composition and use US Patent  US8476295 Publication Date 7/2/2013 
Target
Name:
Rho-associated protein kinase 2 [11-552]
Synonyms:
KIAA0619 | ROCK2 | ROCK2_HUMAN | Rho kinase 2 (ROCKII) | Rho-associated protein kinase 2
Type:
Protein
Mol. Mass.:
62268.16
Organism:
Homo sapiens (Human)
Description:
Chemicon #14-451
Residue:
542
Sequence:
PGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENLLLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQI
  
Inhibitor
Name:
BDBM97666
Synonyms:
US8476295, 1.1.04
Type:
Small organic molecule
Emp. Form.:
C24H30N4O2
Mol. Mass.:
406.5206
SMILES:
Cc1ccc(CN2C3CCC2CC(C3)Nc2ccc3[nH]ncc3c2)cc1OCCO |THB:14:12:8.9:6|
Structure:
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