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Target
Rho-associated protein kinase 2 [11-552]
Ligand
BDBM97667
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
7.2±0
Ki
220±0.0 nM
Citation
 Lampe, JW; Watson, PS; Slade, DJ Bridged bicyclic RHO kinase inhibitor compounds, composition and use US Patent  US8476295 Publication Date 7/2/2013 
Target
Name:
Rho-associated protein kinase 2 [11-552]
Synonyms:
KIAA0619 | ROCK2 | ROCK2_HUMAN | Rho kinase 2 (ROCKII) | Rho-associated protein kinase 2
Type:
Protein
Mol. Mass.:
62268.16
Organism:
Homo sapiens (Human)
Description:
Chemicon #14-451
Residue:
542
Sequence:
PGAPETAPGDGAGASRQRKLEALIRDPRSPINVESLLDGLNSLVLDLDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTCMKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKNDQWHWDNIRETAAPVVPELSSDIDSSNFDDIEDDKGDVETFPIPKAFVGNQLPFIGFTYYRENLLLSDSPSCRETDSIQSRKNEESQEIQKKLYTLEEHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNAEYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQI
  
Inhibitor
Name:
BDBM97667
Synonyms:
US8476295, 2.1.01
Type:
Small organic molecule
Emp. Form.:
C21H24N4
Mol. Mass.:
332.4421
SMILES:
C(N1C2CCC1CC(C2)Nc1cccc2[nH]ncc12)c1ccccc1 |THB:9:7:3.4:1|
Structure:
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