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Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM97725
Substrate
n/a
Meas. Tech.
Enzyme Assay
pH
7.4±n/a
Temperature
310.15±n/a K
IC50
1.29e+3±n/a nM
Comments
extracted
Citation
 Valeur, E; Lepifre, F; Roche, D; Carniato, D; Christmann-Franck, S; Schmidlin, F Fused pyrrolidino-cyclopropane derivatives as selective 11-beta-hydroxysteroid dehydrogenase type 1 inhibitors US Patent  US8486964 Publication Date 7/16/2013 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | DHI1_RAT | Hsd11 | Hsd11b1
Type:
Enzyme
Mol. Mass.:
31889.48
Organism:
Rattus norvegicus (rat)
Description:
P16232
Residue:
288
Sequence:
MKKYLLPVLVLCLGYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMAFAERFVVEAGKLLGGLDMLILNHITQTTMSLFHDDIHSVRRSMEVNFLSYVVLSTAALPMLKQSNGSIAIISSMAGKMTQPLIASYSASKFALDGFFSTIRKEHLMTKVNVSITLCVLGFIDTETALKETSGIILSQAAPKEECALEIIKGTVLRKDEVYYDKSSWTPLLLGNPGRRIMEFLSLRSYNRDLFVSN
  
Inhibitor
Name:
BDBM97725
Synonyms:
US8476267, 2
Type:
Small organic molecule
Emp. Form.:
C22H20ClN3O
Mol. Mass.:
377.867
SMILES:
Clc1ccc(cc1)C1(CC1)C(=O)N1CCC2(CC12)c1c[nH]c2ncccc12
Structure:
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