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Target
MAP kinase-interacting serine/threonine-protein kinase 2
Ligand
BDBM98036
Substrate
n/a
Meas. Tech.
In Vitro Kinase Assay
pH
7.4±0
IC50
6e+1±n/a nM
Citation
 Austen, M; Black, P; Blackaby, W; Danilewicz, J; Linney, I; Schreiter, K; Schneider, M Thienopyrimidines for pharmaceutical compositions US Patent  US8486953 Publication Date 7/16/2013 
Target
Name:
MAP kinase-interacting serine/threonine-protein kinase 2
Synonyms:
GPRK7 | MAP kinase signal-integrating kinase 2 | MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2) | MAP kinase-interacting serine/threonine-protein kinase 2 (MnK2) | MAP-kinase interacting kinase 2 (MNK2) | MKNK2 | MKNK2_HUMAN | MNK2
Type:
Protein
Mol. Mass.:
51870.79
Organism:
Homo sapiens (Human)
Description:
Q9HBH9
Residue:
465
Sequence:
MVQKKPAELQGFHRSFKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAKKRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCAPENTLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDEDLAEEEAAGQGQPVLVRATSRCLQLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
  
Inhibitor
Name:
BDBM98036
Synonyms:
US8486953, 19
Type:
Small organic molecule
Emp. Form.:
C18H18FN3O3S
Mol. Mass.:
375.417
SMILES:
COC(=O)c1sc2ncnc(Nc3ccc(F)cc3OC(C)C)c2c1C
Structure:
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