Reaction Details Report a problem with these data
Target
Probable nicotinate-nucleotide adenylyltransferase
Ligand
BDBM98094
Substrate
n/a
Meas. Tech.
NaMNAT HPLC Enzyme Assay
pH
7.5±0
Temperature
273.15±0 K
IC50
>150000±0.0 nM
Citation
 Moro, WB; Yang, Z; Kane, TA; Zhou, Q; Harville, S; Brouillette, CG; Brouillette, WJ SAR studies for a new class of antibacterial NAD biosynthesis inhibitors. J Comb Chem 11:617-25 (2009) [PubMed]  Article 
Target
Name:
Probable nicotinate-nucleotide adenylyltransferase
Synonyms:
BAMEG_4595 | Deamido-NAD(+) diphosphorylase | Deamido-NAD(+) pyrophosphorylase | NADD_BACAC | Nicotinate mononucleotide adenylyltransferase | Nicotinate-nucleotide adenylyltransferase | Nicotinate-nucleotide adenylyltransferase (NadD) | Nicotinic acid mononucleotide adenylyltransferase (NaMNAT) | nadD
Type:
Enzyme
Mol. Mass.:
21955.08
Organism:
Bacillus anthracis
Description:
C3L5T6
Residue:
189
Sequence:
MRKIGIIGGTFDPPHYGHLLIANEVYHALNLEEVWFLPNQIPPHKQGRNITSVESRLQMLELATEAEEHFSICLEELSRKGPSYTYDTMLQLTKKYPDVQFHFIIGGDMVEYLPKWYNIEALLDLVTFVGVARPGYKLRTPYPITTVEIPEFAVSSSLLRERYKEKKTCKYLLPEKVQVYIERNGLYES
  
Inhibitor
Name:
BDBM98094
Synonyms:
1-(2-nitrophenyl)-3-[4-(o-tolylsulfonylamino)phenyl]urea | Compound ID 7{3,1}
Type:
Small organic molecule
Emp. Form.:
C20H18N4O5S
Mol. Mass.:
426.446
SMILES:
Cc1ccccc1S(=O)(=O)Nc1ccc(NC(=O)Nc2ccccc2[N+]([O-])=O)cc1
Structure:
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