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Target
Glutaminyl-peptide cyclotransferase
Ligand
BDBM98188
Substrate
n/a
Meas. Tech.
Spectrophotometic Assay
Ki
53.5±n/a nM
IC50
297±n/a nM
Citation
 Heiser, U; Ramsbeck, D; Sommer, R; Meyer, A; Hoffmann, T; Boehme, L; Demuth, H Inhibitors US Patent  US8486940 Publication Date 7/16/2013 
Target
Name:
Glutaminyl-peptide cyclotransferase
Synonyms:
Glutaminyl Cyclase | Glutaminyl cyclase (QC) | Glutaminyl-peptide cyclotransferase | Glutaminyl-peptide cyclotransferase precursor (QC) | Glutaminyl-tRNA cyclotransferase | Glutamyl cyclase (QC) | QPCT | QPCT_HUMAN
Type:
Enzyme
Mol. Mass.:
40877.05
Organism:
Homo sapiens (Human)
Description:
Q16769
Residue:
361
Sequence:
MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGTSISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSFSNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLSLKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHGMDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYGGVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLHL
  
Inhibitor
Name:
BDBM98188
Synonyms:
US8486940, 142
Type:
Small organic molecule
Emp. Form.:
C23H19N3O3
Mol. Mass.:
385.4153
SMILES:
COc1ccc(cc1OC)[C@@H]1N(C(=O)c2ccccc12)c1ccc2nc[nH]c2c1 |r|
Structure:
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