Reaction Details Report a problem with these data
Target
Kallikrein-7
Ligand
BDBM100000
Substrate
n/a
EC50
68293±n/a nM
Citation
 PubChem, PC Fluorescence Intensity-based biochemical primary high throughput dose response assay to identify activators of kallikrein-7 (K7) zymogen PubChem Bioassay (2013)[AID] 
Target
Name:
Kallikrein-7
Synonyms:
KLK7 | KLK7_HUMAN | Kallikrein 7 | Kallikrein-7 | PRSS6 | SCCE | Serine protease 6 | Stratum corneum chymotryptic enzyme | hK7 | hSCCE | kallikrein-7 isoform 1 preproprotein
Type:
PROTEIN
Mol. Mass.:
27535.05
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1469257
Residue:
253
Sequence:
MARSLLLPLQILLLSLALETAGEEAQGDKIIDGAPCARGSHPWQVALLSGNQLHCGGVLVNERWVLTAAHCKMNEYTVHLGSDTLGDRRAQRIKASKSFRHPGYSTQTHVNDLMLVKLNSQARLSSMVKKVRLPSRCEPPGTTCTVSGWGTTTSPDVTFPSDLMCVDVKLISPQDCTKVYKDLLENSMLCAGIPDSKKNACNGDSGGPLVCRGTLQGLVSWGTFPCGQPNDPGVYTQVCKFTKWINDTMKKHR
  
Inhibitor
Name:
BDBM100000
Synonyms:
6-chloranyl-8-[(4-methylpiperazin-1-yl)methyl]-7-oxidanyl-4-phenyl-chromen-2-one | 6-chloro-7-hydroxy-8-[(4-methyl-1-piperazinyl)methyl]-4-phenyl-1-benzopyran-2-one | 6-chloro-7-hydroxy-8-[(4-methylpiperazin-1-yl)methyl]-4-phenylchromen-2-one | 6-chloro-7-hydroxy-8-[(4-methylpiperazino)methyl]-4-phenyl-coumarin | MLS000036895 | SMR000042457 | cid_5389374
Type:
Small organic molecule
Emp. Form.:
C21H21ClN2O3
Mol. Mass.:
384.856
SMILES:
CN1CCN(Cc2c(O)c(Cl)cc3c(cc(=O)oc23)-c2ccccc2)CC1
Structure:
Search PDB for entries with ligand similarity: