Reaction Details Report a problem with these data
Target
COUP transcription factor 2
Ligand
BDBM89401
Substrate
n/a
IC50
2579±n/a nM
Citation
 PubChem, PC Luminescence-based cell-based high throughput dose response assay to identify inhibitors of COUP-TFII (NR2F2) PubChem Bioassay (2013)[AID] 
Target
Name:
COUP transcription factor 2
Synonyms:
ARP1 | COT2_HUMAN | COUP transcription factor 2 isoform a | NR2F2 | TFCOUP2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45583.83
Organism:
Homo sapiens (Human)
Description:
gi_14149746
Residue:
414
Sequence:
MAMVVSTWRDPQDEVPGSQGSQASQAPPVPGPPPGAPHTPQTPGQGGPASTPAQTAAGGQGGPGGPGSDKQQQQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRNCPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPTHGQFALTNGDPLNCHSYLSGYISLLLRAEPYPTSRFGSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITDQVALLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVEKLKALHVDSAEYSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRFGKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMAIQ
  
Inhibitor
Name:
BDBM89401
Synonyms:
MLS001126732 | SMR000657962 | [3-(3-hydroxypropyl)-1-piperidinyl]-[5-(5-isoquinolinyloxymethyl)-3-isoxazolyl]methanone | [3-(3-hydroxypropyl)piperidin-1-yl]-[5-(isoquinolin-5-yloxymethyl)-1,2-oxazol-3-yl]methanone | [3-(3-hydroxypropyl)piperidino]-[5-(5-isoquinolyloxymethyl)isoxazol-3-yl]methanone | [5-(isoquinolin-5-yloxymethyl)-1,2-oxazol-3-yl]-[3-(3-oxidanylpropyl)piperidin-1-yl]methanone | cid_24792035
Type:
Small organic molecule
Emp. Form.:
C22H25N3O4
Mol. Mass.:
395.4516
SMILES:
OCCCC1CCCN(C1)C(=O)c1cc(COc2cccc3cnccc23)on1
Structure:
Search PDB for entries with ligand similarity: