Reaction Details Report a problem with these data
Target
Carbamoyl-phosphate synthase small chain
Ligand
BDBM100279
Substrate
n/a
pH
7.5±0
Temperature
298.15±0 K
Kd
3.3e+4± 7e+3 nM
Citation
 Kasprzak, AA; Villafranca, JJ Interactive binding between the substrate and allosteric sites of carbamoyl-phosphate synthetase. Biochemistry 27:8050-6 (1988) [PubMed]  Article 
Target
Name:
Carbamoyl-phosphate synthase small chain
Synonyms:
CARA_ECOLI | Carbamoyl-phosphate synthase (H353N) | Carbamoyl-phosphate synthetase | carA | pyrA
Type:
Protein
Mol. Mass.:
41429.00
Organism:
Escherichia coli (strain K12)
Description:
P0A6F1
Residue:
382
Sequence:
MIKSALLVLEDGTQFHGRAIGATGSAVGEVVFNTSMTGYQEILTDPSYSRQIVTLTYPHIGNVGTNDADEESSQVHAQGLVIRDLPLIASNFRNTEDLSSYLKRHNIVAIADIDTRKLTRLLREKGAQNGCIIAGDNPDAALALEKARAFPGLNGMDLAKEVTTAEAYSWTQGSWTLTGGLPEAKKEDELPFHVVAYDFGAKRNILRMLVDRGCRLTIVPAQTSAEDVLKMNPDGIFLSNGPGDPAPCDYAITAIQKFLETDIPVFGICLGHQLLALASGAKTVKMKFGHHGGNHPVKDVEKNVVMITAQNHGFAVDEATLPANLRVTHKSLFDGTLQGIHRTDKPAFSFQGHPEASPGPHDAAPLFDHFIELIEQYRKTAK
  
Inhibitor
Name:
BDBM100279
Synonyms:
Etheno-AMP | US11185100, TABLE 7.4 | [(2R,3S,4R,5R)-3,4-dihydroxy-5-imidazo[2,1-f]purin-3-yloxolan-2-yl]methyl dihydrogen phosphate
Type:
Small organic molecule
Emp. Form.:
C12H14N5O7P
Mol. Mass.:
371.2426
SMILES:
O[C@@H]1[C@@H](COP(O)(O)=O)O[C@H]([C@@H]1O)n1cnc2c3nccn3cnc12
Structure:
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