Reaction Details Report a problem with these data
Target
Epoxide hydrolase 1
Ligand
BDBM25744
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
11.5±0.0 nM
Citation
 Hammock, BD; Jones, PD; Morisseau, C; Huang, H; Tsai, H; Gless, Jr., R Conformationally restricted urea inhibitors of soluble epoxide hydrolase US Patent  US8501783 Publication Date 8/6/2013 
Target
Name:
Epoxide hydrolase 1
Synonyms:
EPHX | EPHX1 | EPOX | Epoxide hydrolase (EH) | Epoxide hydrolase (HsEH) | Epoxide hydrolase 1 | HYEP_HUMAN | Microsomal epoxide hydrolase
Type:
Protein
Mol. Mass.:
52954.28
Organism:
Homo sapiens (Human)
Description:
P07099
Residue:
455
Sequence:
MWLEILLTSVLGFAIYWFISRDKEETLPLEDGWWGPGTRSAAREDDSIRPFKVETSDEEIHDLHQRIDKFRFTPPLEDSCFHYGFNSNYLKKVISYWRNEFDWKKQVEILNRYPHFKTKIEGLDIHFIHVKPPQLPAGHTPKPLLMVHGWPGSFYEFYKIIPLLTDPKNHGLSDEHVFEVICPSIPGYGFSEASSKKGFNSVATARIFYKLMLRLGFQEFYIQGGDWGSLICTNMAQLVPSHVKGLHLNMALVLSNFSTLTLLLGQRFGRFLGLTERDVELLYPVKEKVFYSLMRESGYMHIQCTKPDTVGSALNDSPVGLAAYILEKFSTWTNTEFRYLEDGGLERKFSLDDLLTNVMLYWTTGTIISSQRFYKENLGQGWMTQKHERMKVYVPTGFSAFPFELLHTPEKWVRFKYPKLISYSYMVRGGHFAAFEEPELLAQDIRKFLSVLERQ
  
Inhibitor
Name:
BDBM25744
Synonyms:
3-(1-acetylpiperidin-4-yl)-1-[4-(trifluoromethoxy)phenyl]urea | US10383835, Compound 1555 | US8501783, 1555 | Urea-based compound, 25
Type:
Small organic molecule
Emp. Form.:
C15H18F3N3O3
Mol. Mass.:
345.3169
SMILES:
CC(=O)N1CCC(CC1)NC(=O)Nc1ccc(OC(F)(F)F)cc1
Structure:
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