Reaction Details
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Pro-glucagon
Ligand
BDBM100847
Substrate
n/a
Meas. Tech.
Glucagon SPA Assay
pH
7.4±0
Ki
65.9±0.0 nM
Citation
Aspnes, GE; Didiuk, MT; Filipski, KJ; Guzman-Perez, A; Lee, EC; Pfefferkorn, JA; Stevens, BD; Tu, MM Glucagon receptor modulators US Patent US8507533 Publication Date 8/13/2013 More Info.:
Target
Name:
Pro-glucagon
Synonyms:
GCG | GLUC_HUMAN | Glucagon | Glucagon receptor (GCGR)
Type:
Enzyme
Mol. Mass.:
20907.95
Organism:
Homo sapiens (Human)
Description:
P01275
Residue:
180
Sequence:
MKSIYFVAGLFVMLVQGSWQRSLQDTEEKSRSFSASQADPLSDPDQMNEDKRHSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRNRNNIAKRHDEFERHAEGTFTSDVSSYLEGQAAKEFIAWLVKGRGRRDFPEEVAIVEELGRRHADGSFSDEMNTILDNLAARDFINWLIQTKITDRK
Inhibitor
Name:
BDBM100847
Synonyms:
US8507533, 163
Type:
Small organic molecule
Emp. Form.:
C25H28ClN5O3
Mol. Mass.:
481.975
SMILES:
Cc1nn(cc1Cl)-c1ccc(NC(C2CCCC2)c2ccc(cc2)C(=O)NCCC(O)=O)cn1
Structure:
