Reaction Details Report a problem with these data
Target
Glutaminyl-peptide cyclotransferase
Ligand
BDBM3740
Substrate
n/a
Meas. Tech.
Spectrophotometric Assay
Temperature
303.15±0 K
Ki
4.6±0.0 nM
IC50
46.1±0.0 nM
Citation
 Heiser, U; Ramsbeck, D Inhibitors US Patent  US8530670 Publication Date 9/10/2013 
Target
Name:
Glutaminyl-peptide cyclotransferase
Synonyms:
Glutaminyl Cyclase | Glutaminyl cyclase (QC) | Glutaminyl-peptide cyclotransferase | Glutaminyl-peptide cyclotransferase precursor (QC) | Glutaminyl-tRNA cyclotransferase | Glutamyl cyclase (QC) | QPCT | QPCT_HUMAN
Type:
Enzyme
Mol. Mass.:
40877.05
Organism:
Homo sapiens (Human)
Description:
Q16769
Residue:
361
Sequence:
MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGTSISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSFSNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLSLKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHGMDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYGGVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLHL
  
Inhibitor
Name:
BDBM3740
Synonyms:
US8530670, 27
Type:
n/a
Emp. Form.:
C26H29N5O2
Mol. Mass.:
443.5408
SMILES:
O=C1C=C(C(N1c1ccc2nc[nH]c2c1)c1ccc(cc1)N1CCOCC1)N1CCCCC1 |c:2|
Structure:
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