Reaction Details Report a problem with these data
Target
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
Ligand
BDBM101889
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
2.6e+2±n/a nM
Citation
 Fukuoka, M; Yokogawa, T; Miyahara, S; Miyakoshi, H; Yano, W; Taguchi, J; Takao, Y Uracil compound or salt thereof having human deoxyuridine triphosphatase inhibitory activity US Patent  US8530490 Publication Date 9/10/2013 
Target
Name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
Synonyms:
DUT | DUT_HUMAN | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) | Deoxyuridine triphosphatase (dUTPase) | dUTP pyrophosphatase
Type:
Enzyme
Mol. Mass.:
26574.03
Organism:
Homo sapiens (Human)
Description:
P33316
Residue:
252
Sequence:
MTPLCPRPALCYHFLTSLLRSAMQNARGARQRAEAAVLSGPGPPLGRAAQHGIPRPLSSAGRLSQGCRGASTVGAAGWKGELPKAGGSPAPGPETPAISPSKRARPAEVGGMQLRFARLSEHATAPTRGSARAAGYDLYSAYDYTIPPMEKAVVKTDIQIALPSGCYGRVAPRSGLAAKHFIDVGAGVIDEDYRGNVGVVLFNFGKEKFEVKKGDRIAQLICERIFYPEIEEVQALDDTERGSGGFGSTGKN
  
Inhibitor
Name:
BDBM101889
Synonyms:
CHEMBL2057599 | US8530490, 159
Type:
Small organic molecule
Emp. Form.:
C21H29N3O6S
Mol. Mass.:
451.536
SMILES:
CC(C)(CCCOCn1ccc(=O)[nH]c1=O)NS(=O)(=O)c1cccc(OCC2CC2)c1
Structure:
Search PDB for entries with ligand similarity: