Reaction Details
Report a problem with these data
Report a problem with these dataTarget
Serine/threonine-protein kinase receptor R3
Ligand
BDBM102619
Substrate
n/a
IC50
3.65±0.0 nM
Citation
Mohedas, AH; Xing, X; Armstrong, KA; Bullock, AN; Cuny, GD; Yu, PB Development of an ALK2-Biased BMP Type I Receptor Kinase Inhibitor. ACS Chem Biol 8:1291-302 (2013) [PubMed] Article More Info.:
Target
Name:
Serine/threonine-protein kinase receptor R3
Synonyms:
AI115505 | AI427544 | ACVL1_MOUSE | Acvrl1 | Acvrlk1 | Alk-1 | ALK1
Type:
Protein
Mol. Mass.:
56529.91
Organism:
Mouse
Description:
n/a
Residue:
502
Sequence:
MTLGSFRRGLLMLSVAFGLTRGDLAKPSKLVNCTCESPHCKRPFCQGSWCTVVLVREQGRHPQVYRGCGSLNQELCLGRPTEFLNHHCCYRSFCNHNVSLMLEATQTPSEEPEVDAHLPLILGPVLALPVLVALGALGLWRVRRRQEKQRDLHSDLGESSLILKASEQADSMLGDFLDSDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGSWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPQLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDLKSRNVLVKSNLQCCIADLGLAVMHSQSSDYLDIGNNPRVGTKRYMAPEVLDEHIRTDCFESYKWTDIWAFGLVLWEIARRTIINGIVEDYRPPFYDMVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKLSHNPEKPKVIH
Inhibitor
Name:
BDBM102619
Synonyms:
K02288a | US10688093, Compound 382_0087_0284 | US11701353, Compound 382_0087_0284
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
COc1cc(cc(OC)c1OC)-c1cc(cnc1N)-c1cccc(O)c1
Structure:
