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Target
Dimer of Gag-Pol polyprotein [489-587]
Ligand
BDBM4247
Substrate
HIV Protease Peptide Substrate
Meas. Tech.
Protease Inhibition Assay
IC50
>1000±n/a nM
Citation
 Takashiro, E; Watanabe, T; Nitta, T; Kasuya, A; Miyamoto, S; Ozawa, Y; Yagi, R; Nishigaki, T; Shibayama, T; Nakagawa, A; Iwamoto, A; Yabe, Y Structure-activity relationship of HIV-1 protease inhibitors containing AHPBA. Part III: Modification of P2 site. Bioorg Med Chem 6:595-604 (1998) [PubMed]  Article 
Target
Name:
Dimer of Gag-Pol polyprotein [489-587]
Synonyms:
HIV-1 Protease
Type:
Protein Complex
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
Gag-Pol polyprotein [489-587]
Synonyms:
HIV protease | HIV-1 Protease (NY5-type sequence) | HIV-1 Protease chain A | HIV-1 Protease chain B | POL_HV1N5 | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10822.21
Organism:
Human immunodeficiency virus type 1
Description:
P12497[489-587]
Residue:
99
Sequence:
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
  
Component 2
Name:
Gag-Pol polyprotein [489-587]
Synonyms:
HIV protease | HIV-1 Protease (NY5-type sequence) | HIV-1 Protease chain A | HIV-1 Protease chain B | POL_HV1N5 | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10822.21
Organism:
Human immunodeficiency virus type 1
Description:
P12497[489-587]
Residue:
99
Sequence:
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
  
Inhibitor
Name:
BDBM4247
Synonyms:
(3aR,6R,7S,7aR)-2,6-dimethoxy-hexahydro-[1,3]dioxolo[4,5-c]pyran-7-yl N-[(2S,3S)-4-[(2S,4S)-2-(tert-butylcarbamoyl)-4-chloropyrrolidin-1-yl]-3-hydroxy-4-oxo-1-phenylbutan-2-yl]carbamate | AHPBA 16 | [3(S) - [2(R) -methoxy- (4(S),5(R) -methoxymethylene)tetra-hydropyranyl]oxy]carbonyl-(2S,3S)-AHPBA-4(S)-Cl-Pro-NH-t-Bu
Type:
Small organic molecule
Emp. Form.:
C28H40ClN3O10
Mol. Mass.:
614.084
SMILES:
COC1O[C@@H]2CO[C@@H](OC)[C@@H](OC(=O)N[C@@H](Cc3ccccc3)[C@H](O)C(=O)N3C[C@@H](Cl)C[C@H]3C(=O)NC(C)(C)C)[C@@H]2O1 |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
HIV Protease Peptide Substrate
Synonyms:
n/a
Type:
Peptide
Mol. Mass.:
2686.50
Organism:
n/a
Description:
n/a
Residue:
24
Sequence:
ACSERGLNASNTYRPRILEVALNH