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Target
DNA polymerase lambda
Ligand
BDBM104084
Substrate
n/a
Meas. Tech.
DNA Pol λ PEX Assay
pH
7.5±n/a
IC50
<1.0e+4±n/a nM
Comments
extracted
Citation
 Strittmatter, T; Brockmann, A; Pott, M; Hantusch, A; Brunner, T; Marx, A Expanding the Scope of Human DNA Polymerase ¿ and ß Inhibitors. ACS Chem Biol 9:282-90 (2014) [PubMed]  Article 
Target
Name:
DNA polymerase lambda
Synonyms:
DNA polymerase lambda (Pol λ) | DPOLL_HUMAN | POLL
Type:
Protein
Mol. Mass.:
63493.10
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
575
Sequence:
MDPRGILKAFPKRQKIHADASSKVLAKIPRREEGEEAEEWLSSLRAHVVRTGIGRARAELFEKQIVQHGGQLCPAQGPGVTHIVVDEGMDYERALRLLRLPQLPPGAQLVKSAWLSLCLQERRLVDVAGFSIFIPSRYLDHPQPSKAEQDASIPPGTHEALLQTALSPPPPPTRPVSPPQKAKEAPNTQAQPISDDEASDGEETQVSAADLEALISGHYPTSLEGDCEPSPAPAVLDKWVCAQPSSQKATNHNLHITEKLEVLAKAYSVQGDKWRALGYAKAINALKSFHKPVTSYQEACSIPGIGKRMAEKIIEILESGHLRKLDHISESVPVLELFSNIWGAGTKTAQMWYQQGFRSLEDIRSQASLTTQQAIGLKHYSDFLERMPREEATEIEQTVQKAAQAFNSGLLCVACGSYRRGKATCGDVDVLITHPDGRSHRGIFSRLLDSLRQEGFLTDDLVSQEENGQQQKYLGVCRLPGPGRRHRRLDIIVVPYSEFACALLYFTGSAHFNRSMRALAKTKGMSLSEHALSTAVVRNTHGCKVGPGRVLPTPTEKDVFRLLGLPYREPAERDW
  
Inhibitor
Name:
BDBM104084
Synonyms:
(Z)-5-(3-Nitro-4-((4-(trifluoromethyl)phenyl)thio)benzylidene)-2- thioxothiazolidin-4-one 18 | DNA polymerase inhibitor 18
Type:
Small organic molecule
Emp. Form.:
C17H9F3N2O3S3
Mol. Mass.:
442.455
SMILES:
[O-][N+](=O)c1cc(C=C2SC(S)=NC2=O)ccc1Sc1ccc(cc1)C(F)(F)F |w:6.5,c:10|
Structure:
Search PDB for entries with ligand similarity: