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Target
Arachidonate 5-lipoxygenase-activating protein
Ligand
BDBM104530
Substrate
n/a
Meas. Tech.
Binding Assay
IC50
2.6±0.0 nM
Citation
 Bartolozzi, A; Bosanac, T; Chen, Z; De Lombaert, S; Dines, JA; Huber, JD; Liu, WW; Loke, PL; Morwick, TM; Olague, A; Riether, D; Tye, H; Wu, L; Zindell, RM Oxadiazole inhibitors of leukotriene production US Patent  US8575201 Publication Date 11/5/2013 
Target
Name:
Arachidonate 5-lipoxygenase-activating protein
Synonyms:
5-lipoxygenase activating protein | 5-lipoxygenase-activating protein (FLAP) | 5-lipoxygenase/FLAP | AL5AP_HUMAN | ALOX5AP | FLAP | MK-886-binding protein
Type:
Enzyme
Mol. Mass.:
18159.90
Organism:
Homo sapiens (Human)
Description:
P20292
Residue:
161
Sequence:
MDQETVGNVVLLAIVTLISVVQNGFFAHKVEHESRTQNGRSFQRTGTLAFERVYTANQNCVDAYPTFLAVLWSAGLLCSQVPAAFAGLMYLFVRQKYFVGYLGERTQSTPGYIFGKRIILFLFLMSVAGIFNYYLIFFFGSDFENYIKTISTTISPLLLIP
  
Inhibitor
Name:
BDBM104530
Synonyms:
US8575201, 21
Type:
Small organic molecule
Emp. Form.:
C24H26N8O2
Mol. Mass.:
458.5156
SMILES:
CC(C)(CO)Nc1ccc(cn1)-c1nc(no1)C1(CCC1)c1ccc(nc1)-c1cnc(N)nc1
Structure:
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