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Target
Lysosomal Pro-X carboxypeptidase
Ligand
BDBM50383422
Substrate
n/a
Meas. Tech.
Enzyme Activity Assay
pH
5.5±0
Temperature
310.15±0 K
IC50
18±0.0 nM
Citation
 Graham, TH; Liu, W; Sebhat, IK; Shen, D; Shi, Z Prolylcarboxypeptidase inhibitors US Patent  US8569299 Publication Date 10/29/2013 
Target
Name:
Lysosomal Pro-X carboxypeptidase
Synonyms:
Angiotensinase C | Lysosomal carboxypeptidase C | PCP | PCP_HUMAN | PRCP | Proline carboxypeptidase | Prolylcarboxypeptidase | Prolylcarboxypeptidase (PRCP)
Type:
Enzyme
Mol. Mass.:
55805.19
Organism:
Homo sapiens (Human)
Description:
P42785
Residue:
496
Sequence:
MGRRALLLLLLSFLAPWATIALRPALRALGSLHLPTNPTSLPAVAKNYSVLYFQQKVDHFGFNTVKTFNQRYLVADKYWKKNGGSILFYTGNEGDIIWFCNNTGFMWDVAEELKAMLVFAEHRYYGESLPFGDNSFKDSRHLNFLTSEQALADFAELIKHLKRTIPGAENQPVIAIGGSYGGMLAAWFRMKYPHMVVGALAASAPIWQFEDLVPCGVFMKIVTTDFRKSGPHCSESIHRSWDAINRLSNTGSGLQWLTGALHLCSPLTSQDIQHLKDWISETWVNLAMVDYPYASNFLQPLPAWPIKVVCQYLKNPNVSDSLLLQNIFQALNVYYNYSGQVKCLNISETATSSLGTLGWSYQACTEVVMPFCTNGVDDMFEPHSWNLKELSDDCFQQWGVRPRPSWITTMYGGKNISSHTNIVFSNGELDPWSGGGVTKDITDTLVAVTISEGAHHLDLRTKNALDPMSVLLARSLEVRHMKNWIRDFYDSAGKQH
  
Inhibitor
Name:
BDBM50383422
Synonyms:
CHEMBL2031594 | US8569299, 74
Type:
Small organic molecule
Emp. Form.:
C28H30ClF3N4O
Mol. Mass.:
531.012
SMILES:
Cc1cc(C2CCN(CC2)C(=O)[C@H]2C[C@@](C)(N)C[C@@H]2c2ccc(F)cc2F)n(n1)-c1ccc(F)c(Cl)c1 |r|
Structure:
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