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Target
Mu-type opioid receptor
Ligand
BDBM50199914
Substrate
n/a
Meas. Tech.
Binding Assay
pH
7.8±0
Temperature
298.15±0 K
Ki
1.1±0.0 nM
IC50
11±0.0 nM
Citation
 Dolle, RE; Le Bourdonnec, B; Goodman, AJ Opioid antagonists US Patent  US8580788 Publication Date 11/12/2013 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50199914
Synonyms:
3-((7R,8R,9alphaR)-2-benzyl-7,8-dimethyl-octahydro-1H-pyrido-[1,2-R]pyrazin-8-yl)phenol | CHEMBL376690 | US8580788, 60
Type:
Small organic molecule
Emp. Form.:
C23H30N2O
Mol. Mass.:
350.4971
SMILES:
C[C@H]1CN2CCN(Cc3ccccc3)C[C@H]2C[C@@]1(C)c1cccc(O)c1 |r|
Structure:
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