Reaction Details
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Probable G-protein coupled receptor 160
Ligand
BDBM281704
Substrate
n/a
Meas. Tech.
GPR120 pERK AlphaScreen SureFire Assay
Temperature
298.15±n/a K
EC50
120±n/a nM
Comments
extracted
Citation
Shi, Y; Wang, Y; Cheng, PT; Wu, SC Cyclobutane containing carboxylic acid GPR120 modulators US Patent US10023519 Publication Date 7/17/2018 More Info.:
Target
Name:
Probable G-protein coupled receptor 160
Synonyms:
G-protein coupled receptor GPCR1 | GP160_HUMAN | GPCR150 | GPR160 | hGPCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39797.81
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
338
Sequence:
MTALSSENCSFQYQLRQTNQPLDVNYLLFLIILGKILLNILTLGMRRKNTCQNFMEYFCISLAFVDLLLLVNISIILYFRDFVLLSIRFTKYHICLFTQIISFTYGFLHYPVFLTACIDYCLNFSKTTKLSFKCQKLFYFFTVILIWISVLAYVLGDPAIYQSLKAQNAYSRHCPFYVSIQSYWLSFFMVMILFVAFITCWEEVTTLVQAIRITSYMNETILYFPFSSHSSYTVRSKKIFLSKLIVCFLSTWLPFVLLQVIIVLLKVQIPAYIEMNIPWLYFVNSFLIATVYWFNCHKLNLKDIGLPLDPFVNWKCCFIPLTIPNLEQIEKPISIMIC
Inhibitor
Name:
BDBM281704
Synonyms:
US10023519, Example 45
Type:
Small organic molecule
Emp. Form.:
C21H23FO3
Mol. Mass.:
342.4039
SMILES:
CC(C)Oc1ccc(F)c(c1)-c1ccc(cc1)[C@@H]1C[C@H](CC(O)=O)C1 |r,wD:17.18,19.21,(-7.63,-4,;-6.86,-2.67,;-5.32,-2.67,;-7.63,-1.33,;-6.86,,;-7.63,1.33,;-6.86,2.67,;-5.32,2.67,;-4.55,4,;-4.55,1.33,;-5.32,,;-3.01,1.33,;-2.24,,;-.7,,;.07,1.33,;-.7,2.67,;-2.24,2.67,;1.61,1.33,;2.69,2.42,;3.78,1.33,;5.32,1.33,;6.09,2.67,;7.63,2.67,;5.32,4,;2.69,.24,)|
Structure:
