Reaction Details
Report a problem with these data
Report a problem with these dataTarget
Probable G-protein coupled receptor 160
Ligand
BDBM281705
Substrate
n/a
Meas. Tech.
GPR120 pERK AlphaScreen SureFire Assay
Temperature
298.15±n/a K
EC50
650±n/a nM
Comments
extracted
Citation
Shi, Y; Wang, Y; Cheng, PT; Wu, SC Cyclobutane containing carboxylic acid GPR120 modulators US Patent US10023519 Publication Date 7/17/2018 More Info.:
Target
Name:
Probable G-protein coupled receptor 160
Synonyms:
G-protein coupled receptor GPCR1 | GP160_HUMAN | GPCR150 | GPR160 | hGPCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39797.81
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
338
Sequence:
MTALSSENCSFQYQLRQTNQPLDVNYLLFLIILGKILLNILTLGMRRKNTCQNFMEYFCISLAFVDLLLLVNISIILYFRDFVLLSIRFTKYHICLFTQIISFTYGFLHYPVFLTACIDYCLNFSKTTKLSFKCQKLFYFFTVILIWISVLAYVLGDPAIYQSLKAQNAYSRHCPFYVSIQSYWLSFFMVMILFVAFITCWEEVTTLVQAIRITSYMNETILYFPFSSHSSYTVRSKKIFLSKLIVCFLSTWLPFVLLQVIIVLLKVQIPAYIEMNIPWLYFVNSFLIATVYWFNCHKLNLKDIGLPLDPFVNWKCCFIPLTIPNLEQIEKPISIMIC
Inhibitor
Name:
BDBM281705
Synonyms:
Cis-3-(3-(2′-fluoro-5′-isopropoxy-[1,1′-biphenyl]-4-yl)cyclobutyl)propanoic acid | US10023519, Example 46
Type:
Small organic molecule
Emp. Form.:
C22H25FO3
Mol. Mass.:
356.4305
SMILES:
CC(C)Oc1ccc(F)c(c1)-c1ccc(cc1)[C@@H]1C[C@H](CCC(O)=O)C1 |r,wD:17.18,19.21,(-8.02,-4,;-7.25,-2.67,;-5.71,-2.67,;-8.02,-1.33,;-7.25,,;-8.02,1.33,;-7.25,2.67,;-5.71,2.67,;-4.94,4,;-4.94,1.33,;-5.71,,;-3.4,1.33,;-2.63,,;-1.09,,;-.32,1.33,;-1.09,2.67,;-2.63,2.67,;1.22,1.33,;2.31,2.42,;3.4,1.33,;4.94,1.33,;5.71,2.67,;7.25,2.67,;8.02,1.33,;8.02,4,;2.31,.24,)|
Structure:
