Reaction Details
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Probable G-protein coupled receptor 160
Ligand
BDBM281712
Substrate
n/a
Meas. Tech.
GPR120 pERK AlphaScreen SureFire Assay
Temperature
298.15±n/a K
EC50
430±n/a nM
Comments
extracted
Citation
Shi, Y; Wang, Y; Cheng, PT; Wu, SC Cyclobutane containing carboxylic acid GPR120 modulators US Patent US10023519 Publication Date 7/17/2018 More Info.:
Target
Name:
Probable G-protein coupled receptor 160
Synonyms:
G-protein coupled receptor GPCR1 | GP160_HUMAN | GPCR150 | GPR160 | hGPCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39797.81
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
338
Sequence:
MTALSSENCSFQYQLRQTNQPLDVNYLLFLIILGKILLNILTLGMRRKNTCQNFMEYFCISLAFVDLLLLVNISIILYFRDFVLLSIRFTKYHICLFTQIISFTYGFLHYPVFLTACIDYCLNFSKTTKLSFKCQKLFYFFTVILIWISVLAYVLGDPAIYQSLKAQNAYSRHCPFYVSIQSYWLSFFMVMILFVAFITCWEEVTTLVQAIRITSYMNETILYFPFSSHSSYTVRSKKIFLSKLIVCFLSTWLPFVLLQVIIVLLKVQIPAYIEMNIPWLYFVNSFLIATVYWFNCHKLNLKDIGLPLDPFVNWKCCFIPLTIPNLEQIEKPISIMIC
Inhibitor
Name:
BDBM281712
Synonyms:
4-(Cis-3-(3-phenoxybenzyloxy)cyclobutyl)butanoic acid | US10023519, Example 53
Type:
Small organic molecule
Emp. Form.:
C21H24O4
Mol. Mass.:
340.4129
SMILES:
OC(=O)CCC[C@H]1C[C@H](C1)OCc1cccc(Oc2ccccc2)c1 |r,wU:8.10,6.5,(10.28,2.47,;8.95,1.7,;8.95,.16,;7.61,2.47,;6.28,1.7,;4.94,2.47,;3.61,1.7,;3.21,.21,;1.72,.61,;2.12,2.1,;.39,-.16,;-.94,.61,;-2.28,-.16,;-2.28,-1.7,;-3.61,-2.47,;-4.94,-1.7,;-4.94,-.16,;-6.28,.61,;-7.61,-.16,;-8.95,.61,;-10.28,-.16,;-10.28,-1.7,;-8.95,-2.47,;-7.61,-1.7,;-3.61,.61,)|
Structure:
