Reaction Details
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Probable G-protein coupled receptor 160
Ligand
BDBM281716
Substrate
n/a
Meas. Tech.
GPR120 pERK AlphaScreen SureFire Assay
Temperature
298.15±n/a K
EC50
700±n/a nM
Comments
extracted
Citation
Shi, Y; Wang, Y; Cheng, PT; Wu, SC Cyclobutane containing carboxylic acid GPR120 modulators US Patent US10023519 Publication Date 7/17/2018 More Info.:
Target
Name:
Probable G-protein coupled receptor 160
Synonyms:
G-protein coupled receptor GPCR1 | GP160_HUMAN | GPCR150 | GPR160 | hGPCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39797.81
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
338
Sequence:
MTALSSENCSFQYQLRQTNQPLDVNYLLFLIILGKILLNILTLGMRRKNTCQNFMEYFCISLAFVDLLLLVNISIILYFRDFVLLSIRFTKYHICLFTQIISFTYGFLHYPVFLTACIDYCLNFSKTTKLSFKCQKLFYFFTVILIWISVLAYVLGDPAIYQSLKAQNAYSRHCPFYVSIQSYWLSFFMVMILFVAFITCWEEVTTLVQAIRITSYMNETILYFPFSSHSSYTVRSKKIFLSKLIVCFLSTWLPFVLLQVIIVLLKVQIPAYIEMNIPWLYFVNSFLIATVYWFNCHKLNLKDIGLPLDPFVNWKCCFIPLTIPNLEQIEKPISIMIC
Inhibitor
Name:
BDBM281716
Synonyms:
2-(2-(3-(3-Phenoxybenzyloxy)cyclobutyl)ethoxy)acetic acid | US10023519, Example 57
Type:
Small organic molecule
Emp. Form.:
C21H24O5
Mol. Mass.:
356.4123
SMILES:
OC(=O)COCCC1CC(C1)OCc1cccc(Oc2ccccc2)c1 |w:7.6,9.11,(10.95,.93,;9.61,1.7,;9.61,3.24,;8.28,.93,;6.94,1.7,;5.61,.93,;4.28,1.7,;2.94,.93,;1.46,1.33,;1.06,-.16,;2.55,-.56,;-.28,-.93,;-1.61,-.16,;-2.94,-.93,;-2.94,-2.47,;-4.28,-3.24,;-5.61,-2.47,;-5.61,-.93,;-6.94,-.16,;-8.28,-.93,;-9.61,-.16,;-10.95,-.93,;-10.95,-2.47,;-9.61,-3.24,;-8.28,-2.47,;-4.28,-.16,)|
Structure:
