Reaction Details
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Probable G-protein coupled receptor 160
Ligand
BDBM281720
Substrate
n/a
Meas. Tech.
GPR120 pERK AlphaScreen SureFire Assay
Temperature
298.15±n/a K
EC50
150±n/a nM
Comments
extracted
Citation
Shi, Y; Wang, Y; Cheng, PT; Wu, SC Cyclobutane containing carboxylic acid GPR120 modulators US Patent US10023519 Publication Date 7/17/2018 More Info.:
Target
Name:
Probable G-protein coupled receptor 160
Synonyms:
G-protein coupled receptor GPCR1 | GP160_HUMAN | GPCR150 | GPR160 | hGPCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39797.81
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
338
Sequence:
MTALSSENCSFQYQLRQTNQPLDVNYLLFLIILGKILLNILTLGMRRKNTCQNFMEYFCISLAFVDLLLLVNISIILYFRDFVLLSIRFTKYHICLFTQIISFTYGFLHYPVFLTACIDYCLNFSKTTKLSFKCQKLFYFFTVILIWISVLAYVLGDPAIYQSLKAQNAYSRHCPFYVSIQSYWLSFFMVMILFVAFITCWEEVTTLVQAIRITSYMNETILYFPFSSHSSYTVRSKKIFLSKLIVCFLSTWLPFVLLQVIIVLLKVQIPAYIEMNIPWLYFVNSFLIATVYWFNCHKLNLKDIGLPLDPFVNWKCCFIPLTIPNLEQIEKPISIMIC
Inhibitor
Name:
BDBM281720
Synonyms:
2-(3-(Trans-1-methyl-3-(3-phenoxyphenyl)cyclobutyl)propoxy)acetic acid | US10023519, Example 61
Type:
Small organic molecule
Emp. Form.:
C22H26O4
Mol. Mass.:
354.4394
SMILES:
C[C@]1(CCCOCC(O)=O)C[C@@H](C1)c1cccc(Oc2ccccc2)c1 |r,wU:11.13,1.0,wD:1.1,(.17,2.75,;.94,1.42,;2.28,2.19,;3.61,1.42,;4.94,2.19,;6.28,1.42,;7.61,2.19,;8.94,1.42,;10.28,2.19,;8.94,-.12,;-.54,1.82,;-.94,.33,;.54,-.07,;-2.28,-.44,;-2.28,-1.98,;-3.61,-2.75,;-4.94,-1.98,;-4.94,-.44,;-6.28,.33,;-7.61,-.44,;-8.94,.33,;-10.28,-.44,;-10.28,-1.98,;-8.94,-2.75,;-7.61,-1.98,;-3.61,.33,)|
Structure:
