Reaction Details
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Probable G-protein coupled receptor 160
Ligand
BDBM281723
Substrate
n/a
Meas. Tech.
GPR120 pERK AlphaScreen SureFire Assay
Temperature
298.15±n/a K
EC50
440±n/a nM
Comments
extracted
Citation
Shi, Y; Wang, Y; Cheng, PT; Wu, SC Cyclobutane containing carboxylic acid GPR120 modulators US Patent US10023519 Publication Date 7/17/2018 More Info.:
Target
Name:
Probable G-protein coupled receptor 160
Synonyms:
G-protein coupled receptor GPCR1 | GP160_HUMAN | GPCR150 | GPR160 | hGPCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39797.81
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
338
Sequence:
MTALSSENCSFQYQLRQTNQPLDVNYLLFLIILGKILLNILTLGMRRKNTCQNFMEYFCISLAFVDLLLLVNISIILYFRDFVLLSIRFTKYHICLFTQIISFTYGFLHYPVFLTACIDYCLNFSKTTKLSFKCQKLFYFFTVILIWISVLAYVLGDPAIYQSLKAQNAYSRHCPFYVSIQSYWLSFFMVMILFVAFITCWEEVTTLVQAIRITSYMNETILYFPFSSHSSYTVRSKKIFLSKLIVCFLSTWLPFVLLQVIIVLLKVQIPAYIEMNIPWLYFVNSFLIATVYWFNCHKLNLKDIGLPLDPFVNWKCCFIPLTIPNLEQIEKPISIMIC
Inhibitor
Name:
BDBM281723
Synonyms:
Trans-3-((2′-fluoro-5′-phenoxy-[1,1′-biphenyl]-4-yl)oxy)cyclobutanecarboxylic acid | US10023519, Example 64
Type:
Small organic molecule
Emp. Form.:
C23H19FO4
Mol. Mass.:
378.393
SMILES:
OC(=O)[C@H]1C[C@@H](C1)Oc1ccc(cc1)-c1cc(Oc2ccccc2)ccc1F |r,wU:5.7,wD:3.2,(8.28,3.15,;6.94,2.38,;6.94,.84,;5.61,3.15,;5.21,4.63,;3.72,4.23,;4.12,2.75,;2.39,5,;1.06,4.23,;1.06,2.69,;-.28,1.93,;-1.61,2.69,;-1.61,4.23,;-.28,5,;-2.94,1.93,;-2.94,.38,;-4.28,-.38,;-4.28,-1.93,;-5.61,-2.69,;-6.94,-1.93,;-8.28,-2.69,;-8.28,-4.23,;-6.94,-5,;-5.61,-4.23,;-5.61,.38,;-5.61,1.93,;-4.28,2.69,;-4.28,4.23,)|
Structure:
