Reaction Details
Report a problem with these data
Report a problem with these dataTarget
1-deoxy-D-xylulose-5-phosphate synthase
Ligand
BDBM108228
Substrate
n/a
Meas. Tech.
DXP Synthase Inhibition Assay
pH
8±n/a
Temperature
310.15±n/a K
Ki
4.22e+5± 8.0e+4 nM
IC50
1.065e+6± 1.90e+5 nM
Comments
extracted
Citation
Morris, F; Vierling, R; Boucher, L; Bosch, J; Freel Meyers, CL DXP synthase-catalyzed C-N bond formation: nitroso substrate specificity studies guide selective inhibitor design. Chembiochem 14:1309-15 (2013) [PubMed] Article More Info.:
Target
Name:
1-deoxy-D-xylulose-5-phosphate synthase
Synonyms:
1-Deoxy-D-xylulose-5-phosphate synthase (DXP synthase)) | DXS_ECOLI | dxs | yajP
Type:
Protein
Mol. Mass.:
67617.17
Organism:
Escherichia coli K-12 (Enterobacteria)
Description:
n/a
Residue:
620
Sequence:
MSFDIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSSGHFASGLGTVELTVALHYVYNTPFDQLIWDVGHQAYPHKILTGRRDKIGTIRQKGGLHPFPWRGESEYDVLSVGHSSTSISAGIGIAVAAEKEGKNRRTVCVIGDGAITAGMAFEAMNHAGDIRPDMLVILNDNEMSISENVGALNNHLAQLLSGKLYSSLREGGKKVFSGVPPIKELLKRTEEHIKGMVVPGTLFEELGFNYIGPVDGHDVLGLITTLKNMRDLKGPQFLHIMTKKGRGYEPAEKDPITFHAVPKFDPSSGCLPKSSGGLPSYSKIFGDWLCETAAKDNKLMAITPAMREGSGMVEFSRKFPDRYFDVAIAEQHAVTFAAGLAIGGYKPIVAIYSTFLQRAYDQVLHDVAIQKLPVLFAIDRAGIVGADGQTHQGAFDLSYLRCIPEMVIMTPSDENECRQMLYTGYHYNDGPSAVRYPRGNAVGVELTPLEKLPIGKGIVKRRGEKLAILNFGTLMPEAAKVAESLNATLVDMRFVKPLDEALILEMAASHEALVTVEENAIMGGAGSGVNEVLMAHRKPVPVLNIGLPDFFIPQGTQEEMRAELGLDAAGMEAKIKAWLA
Inhibitor
Name:
BDBM108228
Synonyms:
1‐nitroso‐2‐naphthol (Substrate 5)
Type:
Small organic molecule
Emp. Form.:
C10H7NO2
Mol. Mass.:
173.1681
SMILES:
Oc1ccc2ccccc2c1N=O
Structure:
