Reaction Details Report a problem with these data
Target
Fatty-acid amide hydrolase 1 [33-574]
Ligand
BDBM108235
Substrate
n/a
IC50
2.6e+4± 6e+3 nM
Citation
 Lambruschini, C; Veronesi, M; Romeo, E; Garau, G; Bandiera, T; Piomelli, D; Scarpelli, R; Dalvit, C Development of fragment-based n-FABS NMR screening applied to the membrane enzyme FAAH. Chembiochem 14:1611-9 (2013) [PubMed]  Article 
Target
Name:
Fatty-acid amide hydrolase 1 [33-574]
Synonyms:
FAAH1_RAT | Faah | Faah1 | Fatty-acid amide hydrolase (rFAAH∆TM)
Type:
Protein
Mol. Mass.:
59459.86
Organism:
Rattus norvegicus (Rat)
Description:
97-1722bp
Residue:
542
Sequence:
GRQKARGAATRARQKQRASLETMDKAVQRFRLQNPDLDSEALLTLPLLQLVQKLQSGELSPEAVFFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHDSTLGLSLNEGMPSESDCVVVQVLKLQGAVPFVHTNVPQSMLSFDCSNPLFGQTMNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKGCVYGQTAVQLSLGPMARDVESLALCLKALLCEHLFTLDPTVPPLPFREEVYRSSRPLRVGYYETDNYTMPSPAMRRALIETKQRLEAAGHTLIPFLPNNIPYALEVLSAGGLFSDGGRSFLQNFKGDFVDPCLGDLILILRLPSWFKRLLSLLLKPLFPRLAAFLNSMRPRSAEKLWKLQHEIEMYRQSVIAQWKAMNLDVLLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMELYKGYFGDIWDIILKKAMKNSVGLPVAVQCVALPWQEELCLRFMREVEQLMTP
  
Inhibitor
Name:
BDBM108235
Synonyms:
1‐(4‐chlorophenyl)‐2,2,2‐trifluoroethanone (Hit 3)
Type:
Small organic molecule
Emp. Form.:
C8H4ClF3O
Mol. Mass.:
208.565
SMILES:
FC(F)(F)C(=O)c1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: