Reaction Details Report a problem with these data
Target
Lipoxygenase
Ligand
BDBM111807
Substrate
n/a
Meas. Tech.
Lipo-oxygenase activity assay
pH
7±n/a
Temperature
298.15±n/a K
IC50
4.783e+4± 5.1e+2 nM
Comments
extracted
Citation
 Ahmad, W; Kumolosasi, E; Jantan, I; Bukhari, SN; Jasamai, M Effects of novel diarylpentanoid analogues of curcumin on secretory phospholipase A2 , cyclooxygenases, lipo-oxygenase, and microsomal prostaglandin E synthase-1. Chem Biol Drug Des 83:670-81 (2014) [PubMed]  Article 
Target
Name:
Lipoxygenase
Synonyms:
Lipoxygenase (LOX)
Type:
Protein
Mol. Mass.:
96302.37
Organism:
Glycine max (Soybean)
Description:
n/a
Residue:
859
Sequence:
MTGGMFGRKGQKIKGTVVLMPKNVLDFNAITSVGKGSAKDTATDFLGKGLDALGHAVDALTAFAGHSISLQLISATQTDGSGKGKVGNEAYLEKHLPTLPTLGARQEAFDINFEWDASFGIPGAFYIKNFMTDEFFLVSVKLEDIPNHGTINFVCNSWVYNFKSYKKNRIFFVNDTYLPSATPGPLVKYRQEELEVLRGDGTGKRRDFDRIYDYDIYNDLGNPDGGDPRPIIGGSSNYPYPRRVRTGREKTRKDPNSEKPGEIYVPRDENFGHLKSSDFLTYGIKSLSQNVIPLFKSIILNLRVTSSEFDSFDEVRGLFEGGIKLPTNILSQISPLPVLKEIFRTDGENTLQFPPPHVIRVSKSGWMTDDEFAREMIAGVNPNVIRRLQEFPPKSTLDPATYGDQTSTITKQQLEINLGGVTVEEAISAHRLFILDYHDAFFPYLTKINSLPIAKAYATRTILFLKDDGSLKPLAIELSKPATVSKVVLPATEGVESTIWLLAKAHVIVNDSGYHQLISHWLNTHAVMEPFAIATNRHLSVLHPIYKLLYPHYKDTININGLARQSLINAGGIIEQTFLPGKYSIEMSSVVYKNWVFTDQALPADLVKRGLAVEDPSAPHGLRLVIEDYPYAVDGLEIWDAIKTWVHEYVSVYYPTNAAIQQDTELQAWWKEVVEKGHGDLKDKPWWPKLQTVEDLIQSCSIIIWTASALHAAVNFGQYPYGGYIVNRPTLARRFIPEEGTKEYDEMVKDPQKAYLRTITPKFETLIDISVIEILSRHASDEVYLGQRDNPNWTTDSKALEAFKKFGNKLAEIEGKITQRNNDPSLKSRHGPVQLPYTLLHRSSEEGMSFKGIPNSISI
  
Inhibitor
Name:
BDBM111807
Synonyms:
2,6-Bis(2,3-dimethoxybenzylidene)cyclohexanone (3)
Type:
Small organic molecule
Emp. Form.:
C24H26O5
Mol. Mass.:
394.4602
SMILES:
COc1cccc(\C=C2/CCC\C(=C/c3cccc(OC)c3OC)C2=O)c1OC
Structure:
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