Reaction Details Report a problem with these data
Target
Cytohesin-3
Ligand
BDBM112784
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Assay
pH
7.5±n/a
Temperature
298.15±n/a K
IC50
40300±n/a nM
Citation
 Degterev, A; Ramana, CV; Miao, B Small molecule antagonists of phosphatidylinositol-3,4,5-triphosphate (PIP3) and uses thereof US Patent  US8628961 Publication Date 1/14/2014 
Target
Name:
Cytohesin-3
Synonyms:
ARNO3 | CYH3_HUMAN | CYTH3 | GRP1 | General receptor of phosphoinositides 1 (GRP1) | PSCD3
Type:
Enzyme
Mol. Mass.:
46340.05
Organism:
Homo sapiens (Human)
Description:
O43739
Residue:
400
Sequence:
MDEDGGGEGGGVPEDLSLEEREELLDIRRRKKELIDDIERLKYEIAEVMTEIDNLTSVEESKTTQRNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGERDEFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPGVFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEELLRNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDPRKPNCFELYNPSHKGQVIKACKTEADGRVVEGNHVVYRISAPSPEEKEEWMKSIKASISRDPFYDMLATRKRRIANKK
  
Inhibitor
Name:
BDBM112784
Synonyms:
US8628961, PIT-1
Type:
Small organic molecule
Emp. Form.:
C14H10ClN3O4S
Mol. Mass.:
351.765
SMILES:
Oc1c(Cl)cc(cc1NC(=S)NC(=O)c1ccccc1)[N+]([O-])=O
Structure:
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