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Target
Glucagon receptor
Ligand
BDBM113046
Substrate
n/a
Meas. Tech.
Glucagon Receptor Binding Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
5900±n/a nM
Comments
extracted
Citation
 DeMong, D; Miller, MW; Dai, X; Stamford, A Substituted imidazolones, compositions containing such compounds and methods of use US Patent  US8633231 Publication Date 1/21/2014 
Target
Name:
Glucagon receptor
Synonyms:
GCGR | GL-R | GLR_HUMAN | Glucagon Receptor (GCGR) | Glucagon receptor (GlucR)
Type:
Enzyme
Mol. Mass.:
54026.92
Organism:
Homo sapiens (Human)
Description:
P47871
Residue:
477
Sequence:
MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
  
Inhibitor
Name:
BDBM113046
Synonyms:
US8633231, 9
Type:
Small organic molecule
Emp. Form.:
C26H30FN7O2
Mol. Mass.:
491.5605
SMILES:
CC(C)(C)CC[C@@H](N1C(=O)C(=NC1(C)C)c1cccc(F)c1)c1ccc(cc1)C(=O)Nc1nnn[nH]1 |r,c:10|
Structure:
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