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Target
Histone deacetylase 1
Ligand
BDBM249365
Substrate
n/a
Meas. Tech.
HDAC Enzyme Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
117±n/a nM
Comments
extracted
Citation
 Mazitschek, R; van Duzer, JH Pyrimidine hydroxy amide compounds as HDAC6 selective inhibitors US Patent  US9884850 Publication Date 2/6/2018 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM249365
Synonyms:
US9464073, 002 | US9884850, Compound 2
Type:
Small organic molecule
Emp. Form.:
C16H16F2N4O3
Mol. Mass.:
350.32
SMILES:
ONC(=O)c1cnc(NC2(CCOCC2)c2cc(F)ccc2F)nc1
Structure:
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