Reaction Details Report a problem with these data
Target
Major prion protein
Ligand
BDBM114306
Substrate
n/a
Meas. Tech.
TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC)
IC50
1078±n/a nM
Citation
 PubChem, PC TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC) PubChem Bioassay (2014)[AID] 
Target
Name:
Major prion protein
Synonyms:
ALTPRP | ASCR | CD_antigen=CD230 | PRIO_HUMAN | PRIP | PRNP | PRP | PrP27-30 | PrP33-35C | Prion protein | major prion protein preproprotein
Type:
PROTEIN
Mol. Mass.:
27671.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_158887
Residue:
253
Sequence:
MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
  
Inhibitor
Name:
BDBM114306
Synonyms:
(2-Ethyl-quinazolin-4-ylsulfanyl)-acetic acid ethyl ester | 2-[(2-ethyl-4-quinazolinyl)thio]acetic acid ethyl ester | 2-[(2-ethylquinazolin-4-yl)thio]acetic acid ethyl ester | MLS000072840 | SMR000003743 | cid_654420 | ethyl 2-(2-ethylquinazolin-4-yl)sulfanylacetate | ethyl 2-(2-ethylquinazolin-4-yl)sulfanylethanoate
Type:
Small organic molecule
Emp. Form.:
C14H16N2O2S
Mol. Mass.:
276.354
SMILES:
CCOC(=O)CSc1nc(CC)nc2ccccc12
Structure:
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