Reaction Details Report a problem with these data
Target
Major prion protein
Ligand
BDBM78909
Substrate
n/a
Meas. Tech.
TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC)
IC50
8722±n/a nM
Citation
 PubChem, PC TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC) PubChem Bioassay (2014)[AID] 
Target
Name:
Major prion protein
Synonyms:
ALTPRP | ASCR | CD_antigen=CD230 | PRIO_HUMAN | PRIP | PRNP | PRP | PrP27-30 | PrP33-35C | Prion protein | major prion protein preproprotein
Type:
PROTEIN
Mol. Mass.:
27671.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_158887
Residue:
253
Sequence:
MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
  
Inhibitor
Name:
BDBM78909
Synonyms:
MLS000776292 | N-(4-methyl-3-morpholin-4-ylsulfonyl-phenyl)-2-quinazolin-4-ylsulfanyl-ethanamide | N-(4-methyl-3-morpholin-4-ylsulfonylphenyl)-2-quinazolin-4-ylsulfanylacetamide | N-(4-methyl-3-morpholinosulfonyl-phenyl)-2-(quinazolin-4-ylthio)acetamide | N-[4-methyl-3-(4-morpholinylsulfonyl)phenyl]-2-(4-quinazolinylthio)acetamide | SMR000371303 | cid_3616560
Type:
Small organic molecule
Emp. Form.:
C21H22N4O4S2
Mol. Mass.:
458.554
SMILES:
Cc1ccc(NC(=O)CSc2ncnc3ccccc23)cc1S(=O)(=O)N1CCOCC1
Structure:
Search PDB for entries with ligand similarity: