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Target
Major prion protein
Ligand
BDBM114417
Substrate
n/a
Meas. Tech.
TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC)
IC50
1245±n/a nM
Citation
 PubChem, PC TRFRET-based cell-based high throughput dose response assay to identify inhibitors of cell surface Prion Protein (PRPC) PubChem Bioassay (2014)[AID] 
Target
Name:
Major prion protein
Synonyms:
ALTPRP | ASCR | CD_antigen=CD230 | PRIO_HUMAN | PRIP | PRNP | PRP | PrP27-30 | PrP33-35C | Prion protein | major prion protein preproprotein
Type:
PROTEIN
Mol. Mass.:
27671.97
Organism:
Homo sapiens (Human)
Description:
ChEMBL_158887
Residue:
253
Sequence:
MANLGCWMLVLFVATWSDLGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQGGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWGQGGGTHSQWNKPSKPKTNMKHMAGAAAAGAVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGSSMVLFSSPPVILLISFLIFLIVG
  
Inhibitor
Name:
BDBM114417
Synonyms:
6-bromanyl-2-(5-ethylthiophen-2-yl)-3-methyl-quinoline-4-carboxylic acid | 6-bromo-2-(5-ethyl-2-thienyl)-3-methyl-cinchoninic acid | 6-bromo-2-(5-ethyl-2-thiophenyl)-3-methyl-4-quinolinecarboxylic acid | 6-bromo-2-(5-ethylthien-2-yl)-3-methylquinoline-4-carboxylic acid | 6-bromo-2-(5-ethylthiophen-2-yl)-3-methylquinoline-4-carboxylic acid | MLS001195884 | SMR000558711 | cid_995260
Type:
Small organic molecule
Emp. Form.:
C17H14BrNO2S
Mol. Mass.:
376.268
SMILES:
CCc1ccc(s1)-c1nc2ccc(Br)cc2c(C(O)=O)c1C
Structure:
Search PDB for entries with ligand similarity: