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Target
Fibrinogen beta chain [164-491]
Ligand
BDBM79646
Substrate
n/a
Meas. Tech.
Fluorescence polarization-based biochemical high throughput dose response assay to identify inhibitors that disrupt the binding of a cyclic peptide (Tn6) to the fibrin proteolytic product D-Dimer
IC50
26055±n/a nM
Citation
 PubChem, PC Fluorescence polarization-based biochemical high throughput dose response assay to identify inhibitors that disrupt the binding of a cyclic peptide (Tn6) to the fibrin proteolytic product D-Dimer and fragment E complex [DD(E )] PubChem Bioassay (2013)[AID] 
Target
Name:
Fibrinogen beta chain [164-491]
Synonyms:
Chain E, Fragment Double-D From Human Fibrin | FGB | FIBB_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
37647.12
Organism:
Homo sapiens (Human)
Description:
gi_28373962
Residue:
328
Sequence:
DNENVVNEYSSELEKHQLYIDETVNSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGWTVIQNRQDGSVDFGRKWDPYKQGFGNVATNTDGKNYCGLPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNALMDGASQLMGENRTMTIHNGMFFSTYDRDNDGWLTSDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGQYTWDMAKHGTDDGVVWMNWKGSWYSMRKMSMKIRPFFPQQ
  
Inhibitor
Name:
BDBM79646
Synonyms:
6-fluoranyl-4-oxidanidyl-7-pyrrolidin-1-yl-2,3-dihydro-1H-cyclopenta[b]quinoxalin-9-ium 9-oxide | 6-fluoro-4-oxido-7-(1-pyrrolidinyl)-2,3-dihydro-1H-cyclopenta[b]quinoxalin-9-ium 9-oxide | 6-fluoro-4-oxido-7-pyrrolidin-1-yl-2,3-dihydro-1H-cyclopenta[b]quinoxalin-9-ium 9-oxide | 6-fluoro-4-oxido-7-pyrrolidino-2,3-dihydro-1H-cyclopenta[b]quinoxalin-9-ium 9-oxide | 6-fluoro-7-pyrrolidin-1-yl-2,3-dihydro-1H-cyclopenta[b]quinoxaline 4,9-dioxide | MLS000045751 | SMR000027708 | cid_3242663
Type:
Small organic molecule
Emp. Form.:
C15H16FN3O2
Mol. Mass.:
289.3048
SMILES:
[O-]N1C2=C(CCC2)[N+](=O)c2cc(N3CCCC3)c(F)cc12 |t:2|
Structure:
Search PDB for entries with ligand similarity: